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I certainly had never done anything like this before. Andersson D. Each time point is divided into two examination days Mondays and Thursdays. Traditionally, human studies investigating sex differences have compared men and women. Associated Data Supplementary Materials Multimedia component 1.

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Gender-affirming treatment includes medical intervention such as inhibition of endogenous sex hormones and subsequent replacement with cross-sex hormones.

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PLoS One. To address issues with over-fitting we will utilize the fact that we have access to several independent datasets albeit not involving hormone treatment with muscle transcriptomic data in relation to relevant clinical characteristics in all the proposed study arms of the project, which can be used for validation and thus minimize the risk for over-fitted models and false discoveries. Pelusi C. Examinations include blood samples, skeletal muscle- adipose- and skin tissue biopsies, arteriography, echocardiography, carotid Doppler examination, whole body MRI, CT of muscle and measurements of muscle strength.

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